Facile synthesis of carboxy methyl chitosan coated iron oxide nanoparticles and their antimicrobial activity

Abstract

Iron oxide nanoparticles have been intensively investigated due to their magnetic characteristics, and their potential applications in the area of bioscience and medicine. Iron oxide nanoparticles with their non-toxic and biocompatible effects can be used in biomedical applications ranging from drug delivery to hyperthermia for tumor targeted therapy. Targeted drug delivery is achieved by super Para magnetism by which the required magnetic alignment is achieved at normal temperature. Surface shaping of iron oxide nanoparticles is done accordingly for coating of plant extracts which acts as the required drug for cancer therapy. Certain plant extracts contains poly phenols which performs the role of reduction and precipitations. such methods do not harm the environment and fall under "Green synthesis". In this work iron oxide nanoparticle has been synthesized by a simple wet chemical reduction using plant phytochemicals and their anti microbial activities were evaluated. The particles showed even size distribution and had anti microbial activity even in minimal concentrations. The resultant particles where analyzed by UV-Visible spectroscopy and particle size analyserby dynamic light scattering DLS and zeta potential measurement.