Simultaneous Determination of Isoproterenol, Acetaminophen and Folic Acid Using Nanostructured Electrochemical Sensor Based on Benzofuran Derivative and Carbon Nanotubes

Abstract

No presente artigo, o uso de pasta de eletrodo de carbono modificada por nanotubos de carbono e derivados de benzofurano (1-(4-(1,3-ditiolan-2-il)-6,7-dihidroxi-2-metil-6,7dihidrobenzofuran-3-il) etanona) para a determinação de isoproterenol (IP) foi descrito.O coeficiente de transferência de carga, α, e a constante de transferência de carga, k s , para a transferência de elétrons entre o derivado de benzofurano e a pasta de eletrodo de carbono foram calculados como 0,52 e 1,04 s -1 , respectivamente.O potencial anódico do IP diminui cerca de 256 mV com esse eletrodo modificado.Picos de corrente de voltametria de pulso diferencial (DPV) do IP, acetaminofeno (AC) e ácido fólico (FA) aumentam linearmente com concentrações na faixa de 0,05-2000 µmol L -1 , 50,0-1200 µmol L -1 e 67,0-1600 µmol L -1 , respectivamente e os limites de detecção para IP, AC e FA foram 0,020 µmol L -1 , 0,385 µmol L -1 e 0,690 µmol L -1 , respectivamente.In the present paper, the use of carbon paste electrode modified by carbon nanotubes and benzofuran derivative (1-(4-(1,3-dithiolan-2-yl)-6,7-dihydroxy-2-methyl-6,7-dihydrobenzofuran-3-yl) ethanone) for the electrocatalytic determination of isoproterenol (IP) was described.The charge transfer coefficient, α, and the charge transfer rate constant, k s , for electron transfer between the benzofuran derivative and the carbon paste electrode were calculated as 0.52 and 1.04 s -1 , respectively.The anodic overpotential of IP is decreased about 256 mV by this modified electrode.Differential pulse voltammetric (DPV) peak currents of IP, acetaminophen (AC) and folic acid (FA) increased linearly with their concentration in the ranges of 0.05-2000.0µmol L -1 , 50.0-1200.0µmol L -1 and 67.0-1600.0µmol L -1 , respectively and the detection limits for IP, AC and FA were 0.020 µmol L -1 , 0.385 µmol L -1 and 0.690 µmol L -1 , respectively.