HISTOLOGIC CHANGES PRODUCED EXPERIMENTALLY IN RABBITS BY THE IODIDS OF POTASSIUM AND SODIM

Abstract

In previous papers, we have reported the results of studies on the histologic changes produced experimentally by the administration of arsphenamin,¹neo-arsphenamin,²mercury³and bismuth.⁴The results have shown that these compounds in certain amounts may produce degenerative effects in some of the internal organs, notably the liver, by arsphenamin and the kidneys by neo-arsphenamin, mercury and bismuth. Since investigations of this kind have proved of value and interest clinically in relation to the chemotherapy of syphilis, and since the iodids are frequently used in conjunction with these substances, a similar study was undertaken to determine their effect on certain organs, that is, the brain, heart, lung, spleen, suprarenal glands, kidney and liver. Investigation on the action of the iodids appears to have been confined largely to clinical and functional studies. We were able to find but few references to previous morphologic work on the organs