Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease
Arndt SchotteliusSusanne WedelRenita WeltrichW. RohdeFrank ButtgereitStefan SchreiberHerbert Lochs
Abstract
Our data show a systemic increase in GR expression and a decrease in the affinity to the GR in IBD, in contrast to other inflammatory diseases such as rheumatoid arthritis and asthma. These changes point towards a systemic character of IBD, which might be considered in a decision between topical and systemic treatment.
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