ChemInform Abstract: Regiodirected Synthesis of Polyfluoroalkylated Pyrimido[1,2‐a]benzimidazoles.

Marina V. Goryaeva; Ya. V. Burgart; В. И. Салоутин; Олег Н. Чупахин

doi:10.1002/chin.201244164

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ChemInform Abstract: Regiodirected Synthesis of Polyfluoroalkylated Pyrimido[1,2‐a]benzimidazoles.

Marina V. Goryaeva Ya. V. Burgart В. И. Салоутин Олег Н. Чупахин

Year: 2012 Journal: ChemInform Vol: 43 (44) Publisher: Wiley

DOI: 10.1002/chin.201244164

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Abstract

Abstract The nature of the solvent used and the length of the fluoroalkyl‐substituent in 3‐oxo‐3‐polyfluoroalkyl‐2‐ethoxymethylidenepropionates prove to be the main features which determine the regioselectivity in the reaction of aminobenzimidazole (II) with the propionates mentioned above.

Keywords:

Chemistry Substituent Regioselectivity Propionates Medicinal chemistry Solvent Combinatorial chemistry Stereochemistry Organic chemistry Catalysis

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Synthesis and Reactions of Organic Compounds

Physical Sciences → Chemistry → Organic Chemistry

Fluorine in Organic Chemistry

Life Sciences → Pharmacology, Toxicology and Pharmaceutics → Pharmaceutical Science

Synthesis and Biological Evaluation

Physical Sciences → Chemistry → Organic Chemistry

ChemInform Abstract: Regiodirected Synthesis of Polyfluoroalkylated Pyrimido[1,2‐a]benzimidazoles.

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