Preparation and evaluation of novel octylmethoxycinnamate‐loaded solid lipid nanoparticles

Abstract

Synopsis Objective Octylmethoxycinnamate ( OMC )‐loaded solid lipid nanoparticles ( SLN s) were prepared by ultrasonic emulsification method. Effects of process variables and formulation composition were investigated on particle size and polydispersity index ( PI ), and the UV absorbance. Effect of OMC concentration on entrapment efficiency (EE) was also studied. Methods The optimal formulation was characterized and evaluated by environment emission scanning electron microscopy ( ESEM ), differential scanning calorimetry ( DSC ) and Fourier transform infrared spectroscopy ( FT ‐ IR ). In addition, the degradations of OMC from SLN s and OMC conventional emulsion were compared. Results The composition of optimal formulation was determined as 5% (w/w) of solid lipid, 7% (w/w) of emulsifier and 9% of loaded OMC , resulting in a particle size of 392.8 nm, and EE of 88.73%, LD of 38.05% under the preparation condition of 6 min of sonication, 400 W of sonication power. ESEM study showed spherical particles with smooth surface. DSC studies indicated OMC encapsulation within the nanoparticle matrix. The characteristic peaks for OMC ‐ SLN s stood at 1710, 1604, 1513, 1465 and 830.3 cm −1 . The degradation rate of OMC was decreased when using SLN s formulations compared to conventional emulsion. Conclusion Hence, the developed SLN s can be used as sunscreen carrier for improve the stability.