Pentoxifylline Attenuates Pulmonary Macromolecular Leakage After Intestinal Ischemia-Reperfusion

Abstract

Pentoxifylline reduces alveolar capillary membrane injury and subsequent protein leakage and improves cardiac output when administered after 30 minutes of intestinal ischemia. These data suggest that pentoxifylline may be a possible candidate as a future therapy for acute pulmonary dysfunction. Further studies in human patients are necessary.