Spermidine Alleviates Severity of Murine Experimental Autoimmune Encephalomyelitis

Xiaoli Guo; Chikako Harada; Kazuhiko Namekata; Atsuko Kimura; Yoshinori Mitamura; Hiroshi Yoshida; Yoh Matsumoto; Takayuki Harada

doi:10.1167/iovs.10-6015

JOURNAL ARTICLE

Spermidine Alleviates Severity of Murine Experimental Autoimmune Encephalomyelitis

Xiaoli Guo Chikako Harada Kazuhiko Namekata Atsuko Kimura Yoshinori Mitamura Hiroshi Yoshida Yoh Matsumoto Takayuki Harada

Year: 2011 Journal: Investigative Ophthalmology & Visual Science Vol: 52 (5)Pages: 2696-2696 Publisher: Cadmus Press

DOI: 10.1167/iovs.10-6015

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Abstract

The results from this study suggest that oral spermidine administration could be a useful treatment for MS.

Keywords:

Spermidine Optic nerve Retinal ganglion cell Experimental autoimmune encephalomyelitis Optic neuritis Medicine Multiple sclerosis Retinal Pathology Immunology Pharmacology Internal medicine Endocrinology Ophthalmology Biology Biochemistry

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Topics

Mast cells and histamine

Life Sciences → Immunology and Microbiology → Immunology

Neuroinflammation and Neurodegeneration Mechanisms

Life Sciences → Neuroscience → Neurology

Polyamine Metabolism and Applications

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

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