Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages

Abstract

Adenosine activates MMP-9 secretion by macrophages through its A3 receptor. The effect is in contrast to that observed in neutrophils, where Ado inhibits MMP-9 secretion by the A2a receptor. These observations may have important implications for therapeutic strategies targeting Ado receptors in the setting of MI.