Study on Antheraea Pernyi Silk Fibroin Microspheres Carried Drug

Abstract

A new method was developed to prepare the Antheraea Pernyi silk fibroin (ASF) microspheres and rhodamine was as a model drug. The structure of ASF microsphere carried drug was β-sheet structure characterized by X-ray diffraction and FTIR. The morphology of microspheres was observed by scanning electron microscope. The diameter of the ASF particles was not changed before and after drug carried. It was in the range of 1 μm to 5μm with a narrow size distribution. The encapsulation rate, drug content, and the drug release were tested. The resulted showed that encapsulation rate was increased and drug content was decreased with the addition of rhodamine increasing. The drug released 70% after 12 days and there was no significant difference with different pH value.