JOURNAL ARTICLE
SPECTROPHOTOMETRIC DETERMINATION OF SOME ANTIDEPRESSANT DRUGS
Wiesława MisiukHelena Puzanowska‐Tarasiewicz
Year: 2002 Journal: Analytical Letters Vol: 35 (7)Pages: 1163-1170 Publisher: Taylor & Francis
Abstract
ABSTRACT Amitriptyline and desipramine hydrochlorides react with niobium (V) thiocyanate complex forming yellow ion-association compounds. These compounds are insoluble in water, but fairly soluble in organic solvents. The formation and extraction conditions of the compounds have been established, and a new spectrophotometric method has been developed for the determination of amitriptyline and desipramine in the concentration range of 1–12 µg/mL and 1–6 µg/mL, respectively.
Keywords:
Chemistry Desipramine Amitriptyline Thiocyanate Chromatography Phenothiazine Extraction (chemistry) Spectrophotometry Antidepressant Organic chemistry Pharmacology
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14
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0.65
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Citation History
Topics
Analytical Methods in Pharmaceuticals
Physical Sciences → Chemistry → Analytical Chemistry
Pharmacological Effects and Assays
Life Sciences → Agricultural and Biological Sciences → Animal Science and Zoology
Analytical Chemistry and Sensors
Physical Sciences → Chemical Engineering → Bioengineering
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