Simultaneous Determination of Caffeine and Acetylsalicylic Acid in Pharmaceutical Formulations Using a Boron‐Doped Diamond Film Electrode by Differential Pulse Voltammetry

Abstract

Abstract This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeatability was reached for 20 measurements, with a low relative standard deviation of less than 1.0 %. The calibration curves presented a great linear correlation coefficient for both drugs ( R =0.999) with a limit of detection of 1.6×10 −7 mol L −1 for CF and 2.3×10 −7 mol L −1 for ASA. The system was validated in comparison with the official method.