Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

Makiko Ono; Nobuyoshi Kosaka; Naoomi Tominaga; Yusuke Yoshioka; Fumitaka Takeshita; Ryou-u Takahashi; Masayuki Yoshida; Hitoshi Tsuda; Kenji Tamura; Takahiro Ochiya

doi:10.1126/scisignal.2005231

JOURNAL ARTICLE

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

Makiko Ono Nobuyoshi Kosaka Naoomi Tominaga Yusuke Yoshioka Fumitaka Takeshita Ryou-u Takahashi Masayuki Yoshida Hitoshi Tsuda Kenji Tamura Takahiro Ochiya

Year: 2014 Journal: Science Signaling Vol: 7 (332)Pages: ra63-ra63 Publisher: American Association for the Advancement of Science

DOI: 10.1126/scisignal.2005231

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Abstract

The bone marrow delivers dormancy signals in exosomes to metastatic cancer cells.

Keywords:

Bone marrow Cancer research Mesenchymal stem cell Biology Cancer cell Stem cell Breast cancer Matrigel Cancer Medicine Immunology Pathology Cell biology Internal medicine Angiogenesis

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1.00

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Citation History

Topics

Extracellular vesicles in disease

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

MicroRNA in disease regulation

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Mesenchymal stem cell research

Health Sciences → Medicine → Genetics

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