JOURNAL ARTICLE

Near-IR Sensitive Au-Au<sub>2</sub>S Nanoparticles with Biocompatibility for Drug Delivery

Wen LiuZuyong WangPei YinLei RenQi Qing Zhang

Year: 2008 Journal:   Advanced materials research Vol: 47-50 Pages: 1315-1318   Publisher: Trans Tech Publications

Abstract

The near-infrared (NIR) sensitive Au-Au2S nanoparticles (NPs) have shown many advantages as potential drug delivery systems. To further investigate biological safety of Au-Au2S NPs, cytotoxicity was estimated by calcein AM/EthD-1 fluorescence staining and the lactate dehydrogenase (LDH) release. The effects of NPs on apoptosis of CHL cells were determined by flow cytometry with Annexin V-FITC/PI double staining. It is evident that the Au-Au2S NPs are non-cytotoxic below IC50 dosage.

Keywords:
Biocompatibility Calcein Cytotoxicity Flow cytometry Drug delivery Lactate dehydrogenase Annexin Nanoparticle Chemistry Staining Fluorescence Nanotechnology Nuclear chemistry Biophysics Apoptosis Molecular biology Materials science Biochemistry In vitro Medicine Organic chemistry Biology Enzyme Pathology

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