3D interferometric optoacoustic imaging

Abstract

We report on the further development of our previously described spectroscopic imaging technique based on time-resolved interferometric measurements of laser-induced thermoelastic expansion (POISe: Pulsed Optoelastic Interferometric Spectroscopy and Imaging). We show the capability of POISe to form tomographic images of tissue phantoms and live animal tissues. By performing image reconstruction on data sets acquired from several tissue-like phantoms we demonstrate the ability of POISe to provide better than 200 μm spatial resolution in a strongly scattering medium (μ′ s=1.5/ mm). Additionally we demonstrate the ability of POISe to image chicken chorio-allantoic membrane (CAM) blood vessels through a 6-10 mm layer of Intralipid with μ′ s=0.75/mm.