Electrochemical behavior and determination of trifluoperazine at decanethiol self-assembled monolayer modified gold electrodes

Abstract

The electrochemical behavior of trifluoperazine at decanethiol self-assembled monolayer (SAM) modified gold electrodes (i. e. C10 H21 SH/Au) has been studied. Triflu operazine can effectively accumulate on C10 H21 SH Au electrodes and generate a sensitive anodic peak at about 0. 63 V (vs. SCE) in 0.05 mol/L pH 9.1 Na2B1O, buffer solution. Under the selected conditions, the anodic peak current was linear to trifluoperazine concentration in the range of 5.0×107–3.0×1015 mol/L with correlation coefficient of 0.997. the detection limit was 3.0×108 mol/L. This method was applied to the determination of trifluoperazine in drug samples and the recovery was 97.30, 101.03 r. It was found that so dium dodecyl sulfate (SDS) could make the anodic peak current increase. In the presence of SDS, the peak at about 0.63 V turned into two peaks, resulting from the change of the electrochemical mechanism.