The Nuclear-Factor κB Pathway Is Activated in Pterygium

Jay Jyh Kuen Siak; See Liang Ng; Li‐Fong Seet; Roger W. Beuerman; Louis Tong

doi:10.1167/iovs.10-5735

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JOURNAL ARTICLE

The Nuclear-Factor κB Pathway Is Activated in Pterygium

Jay Jyh Kuen Siak See Liang Ng Li‐Fong Seet Roger W. Beuerman Louis Tong

Year: 2010 Journal: Investigative Ophthalmology & Visual Science Vol: 52 (1)Pages: 230-230 Publisher: Cadmus Press

DOI: 10.1167/iovs.10-5735

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Abstract

The NF-κB pathway is shown for the first time to be activated in pterygia tissues compared with normal conjunctiva tissues. Stimulation by the inflammatory cytokine TNF-α can activate both canonical and noncanonical NF-κB pathways in pterygium fibroblasts with concomitant upregulation of NF-κB target genes.

Keywords:

RELB Western blot Pterygium Molecular biology Blot Conjunctiva Tumor necrosis factor alpha P50 Fibroblast Transcription factor Pathogenesis Pathology Medicine Chemistry Immunology Biology Cell culture Gene

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Corneal Surgery and Treatments

Health Sciences → Medicine → Radiology, Nuclear Medicine and Imaging

NF-κB Signaling Pathways

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Immune Response and Inflammation

Life Sciences → Immunology and Microbiology → Immunology

The Nuclear-Factor κB Pathway Is Activated in Pterygium

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