Trimethoprimium 3,5-dinitrosalicylate

Annamalai Subashini; S. Ebenezer; Packianathan Thomas Muthiah; G. Bocelli; A. Cantoni

doi:10.1107/s160053680704189x

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JOURNAL ARTICLE

Trimethoprimium 3,5-dinitrosalicylate

Annamalai Subashini S. Ebenezer Packianathan Thomas Muthiah G. Bocelli A. Cantoni

Year: 2007 Journal: Acta Crystallographica Section E Structure Reports Online Vol: 63 (10)Pages: o4049-o4049 Publisher: International Union of Crystallography

DOI: 10.1107/s160053680704189x

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Abstract

In the title compound [systematic name: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidinium 2-hydroxy-3,5-dinitrobenzoate], C14H19N4O3+·C7H3N2O7−, the trimethoprimium (TMP) cation is protonated at one of the pyrimidine N atoms. The protonated N atom and the 2-amino group of the TMP cation interact with the carboxylate group of the 3,5-dinitrosalicylate anion through a pair of N—H⋯O hydrogen bonds. A typical intramolecular O—H⋯O hydrogen bond is observed in the anion.

Keywords:

Protonation Chemistry Hydrogen bond Pyrimidine Medicinal chemistry Ion Group (periodic table) Stereochemistry Crystallography Molecule Organic chemistry

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Crystal structures of chemical compounds

Physical Sciences → Chemistry → Inorganic Chemistry

Structural and Chemical Analysis of Organic and Inorganic Compounds

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and biological activity

Physical Sciences → Chemistry → Organic Chemistry

Trimethoprimium 3,5-dinitrosalicylate

Abstract

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