Cyclic Voltammetric Studies of Simvastatin at Glassy Carbon Electrode Modified with Poly(p-toluene sulfonic acid).

Abstract

Glassy carbon electrode (GCE) is modified with electropolymerised film of p-toluene sulfonic acid (p-TSA). This polymer (p-TSA) modified electrode is used to study the electrochemical behavior of simvastatin (SMV), a lipid lowering drug in aqueous alcohol medium by Cyclic Voltammetry. It was found that the oxidation peak current of simvastatin at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH, supporting electrolyte concentration, % of solvent and concentration of simvastatin were examined. The proposed method was sensitive and simple. It was successfully employed to determine simvastatin in pharmaceutical samples.