ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF PHYLLANTHUS RHEEDII ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Abstract

The aim of this study was to investigate the effects of ethanolic extract of the whole plant of Phyllanthus rheedii wight P.rheedii as antihyperglycemic, antihyperlipidemic and antioxidant effect in streptozotocin (STZ) induced diabetic rats. Male Wistar rats were administered P.rheedii (250 mg/kg) orally for 21 days and blood glucose level was measured weekly. At the end of 21 days, the serum lipid metabolites such as total cholesterol, triglycerides, high density lipoproteins (HDL) and protein metabolites such as total protein, albumin, globulin and albumin:globulin ratio (A:G) enzyme level viz serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) were determined. In order to determine antioxidant activity of extract, liver tissues were homogenized in ice cold saline buffer and the assay of lipid peroxides (LPO), superoxide dismutase (SOD) and catalase (CAT) were performed in control, STZ and extract treated rats. All these effects were compared with glibenclamide as a reference antidiabetic drug. Oral administration of P.rheedii for 21 days resulted in a significant reduction in blood glucose level, lipid metabolism and enzymes level and significant improvement in LPO, SOD and catalase in liver tissues of STZ induced diabetic rats when compared with untreated diabetic rats. The protein metabolites were significantly altered near to normal. The effects produced by the extract were comparable to that of glibenclamide. In conclusion The P.rheedii showed significant antihyperglycemic, antihyperlipidemic and antioxidants effect in STZ induced diabetic rats.