Glioblastoma stem cells resistant to temozolomide-induced autophagy.
Jun FuZhigang LiuXiaomei LiuFu‐Rong ChenShi Hong-liuChung-sean PangjesseHo‐Keung NgZhongping Chen
Abstract
The GSCs display strong capability of tumor's resistance to TMZ. This resistance is probably contributed by the CD133(+) cells with down-regulation of autophagy-related proteins. Future treatment should target this small population of cancer stem cells in tumors to improve survival of patients.
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