Heparinizable materials, 5. Preparation and FTIR characterization of polyurethane surfaces grafted with heparin‐complexing poly(amido‐amine) chains

Abstract

Abstract The chains of poly(amido‐amine) ( 1 ) were grafted on the surface of two different polyurethanes ( 2 and 3 ), one of which being a commercial product. All the chemical steps of the grafting reaction were monitored by chemical analysis and FTIR spectroscopy. The poly(amido‐amine) was found to be able to form a complex with heparin by electrostatic interaction. The heparin can be totally removed by using a 0,1 M NaOH solution. The heparin adsorbing capacity of the two resulting materials was biologically tested. A constant heparin/poly(amido‐amine) ratio, observed for both polyurethane samples, leads to the assumption that the complex formation reaction proceeds via a defined stoichiometry.